Effect of Morphine on ‘Wet-Dog’ Shakes Caused by Cerebroventricular Injection of Serotonin

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Abstract
Intraventricular administration of serotonin to rats causes ‘wet-dog’ shakes, a sign of morphine withdrawal. The frequency of shakes is dose-dependent. Shaking is potentiated by pretreatment with an inhibitor of monoamine oxidase or with 5,7-dihydroxytryptamine, and is depressed by morphine or serotonin receptor blockers. Depression of serotonin-induced shaking by morphine is reversed rapidly by naloxone. However, naloxone did not reverse the inliibition of ‘wet-dog’ shakes caused by serotonin receptor blockers.