Failure of Transfer-Factor Therapy in Chronic Active Type B Hepatitis

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Abstract
Chronic active type B hepatitis, a disorder caused by the hepatitis B virus, is characterized by progressive hepatocellular damage leading to cirrhosis, portal hypertension and, in some cases, to hepatocellular carcinoma.1 Factors that allow persistent viral replication and continuous liver-cell necrosis in these patients are poorly understood, although it has been postulated that a deranged cellular immune response to invasion by the hepatitis B virus2 or decreased interferon production3 in the host may be involved. Abnormal lymphocyte-mediated responses to HBs Ag have recently been demonstrated in patients with chronic active Type B hepatitis.4 5 6 7 8 We attempted to correct the immune . . .