Does unequal crossing over contribute to the mutation rate in Duchenne muscular dystrophy?
- 1 August 1982
- journal article
- research article
- Published by Wiley in American Journal of Medical Genetics
- Vol. 12 (4) , 437-441
- https://doi.org/10.1002/ajmg.1320120407
Abstract
In order to explain the high mutation rate in Duchenne muscular dystrophy (DMD), together with the apparent equal incidence of new mutations in sperms and ova, which is unusual when compared with other X‐linked conditions, it is postulated that a significant proportion of new mutations in DMD are caused by unequal crossing over in females at meiosis. If this is true, then there are important consequences for the strategy of research into the molecular basis of DMD.Keywords
This publication has 16 references indexed in Scilit:
- Some comments on penetrance and related subjectsAmerican Journal of Medical Genetics, 1981
- Human fetal gγ- and Aγ-globin genes: Complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genesCell, 1980
- The structure of a human α-globin pseudogene and its relationship to α-globin gene duplicationCell, 1980
- Molecular cloning and characterization of the human β-like globin gene clusterCell, 1980
- Frequency of new mutants among boys with Duchenne muscular dystrophyAmerican Journal of Medical Genetics, 1980
- Recent developments in the molecular genetics of human hemoglobinCell, 1979
- Systemic Membrane Defect in the Proximal Muscular DystrophiesNew England Journal of Medicine, 1978
- The use and limitations of chiasma scoring with reference to human genetic mappingCytogenetic and Genome Research, 1978
- Biochemistry of meiosisPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1977
- The rate of spontaneous mutation of a human geneJournal of Genetics, 1935