DIFFUSE PARENCHYMAL AMYLOIDOSIS OF LUNGS AND BREAST - ITS ASSOCIATION WITH DIFFUSE PLASMACYTOSIS AND KAPPA-CHAIN GAMMOPATHY

  • 1 January 1979
    • journal article
    • research article
    • Vol. 103  (11) , 583-585
Abstract
A patient had systemic amyloidosis that extensively involved the lungs and breasts. Diffuse parenchymal pulmonary amyloidosis is rare but well described. Involvement of the breast in systemic amyloidosis is, however, most unusual. This patient''s amyloidosis was associated with diffuse plasmacytosis and a .kappa.-chain gammopathy. The plasmacytosis was most prominent in the renal interstitium. Immunoperoxidase staining of the renal infiltrate and breast demonstrated Ig[immunoglobulin]G/.kappa.-staining plasma cells exclusively, suggesting that these cells were a monoclonal [M] proliferation that contributed to the patient''s M-protein and possibly to the patient''s amyloid deposits.