Measles Virus Genome in Infections of the Central Nervous System
- 1 August 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 144 (2) , 154-160
- https://doi.org/10.1093/infdis/144.2.154
Abstract
The measles virus genome was traced in acute and chronic infections of the central nervous system in hamsters and humans. The extent of viral replication and gene expression was assessed by the techniques of in situ hybridization and immunofluorescence. Both replication and gene expression were restricted in chronically infected hamsters and in humans with subacute sclerosing panencephalitis. It is proposed that restriction playsan important role in persistence of measles virus and the slow evolution of disease in these and other slow infections.This publication has 7 references indexed in Scilit:
- Measles Virus Nucleotide Sequences: Detection by Hybridization in SituScience, 1981
- Detection of viral sequences of low reiteration frequency by in situ hybridization.Proceedings of the National Academy of Sciences, 1978
- Subclasses of ribonucleoproteins in influenza virus-infected cellsVirology, 1978
- Acetylation of chromosome squashes of Drosophila melanogaster decreases the background in autoradiographs from hybridization with [125I]-labeled RNA.Journal of Histochemistry & Cytochemistry, 1978
- Use of the avidin-biotin complex for the localization of actin and myosin with fluorescence microscopy.The Journal of cell biology, 1977
- Slow Persistent Infection Caused by Visna Virus: Role of Host RestrictionScience, 1977
- Efficient transcription of RNA into DNA by avian sarcoma virus polymeraseBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1976