Inhibitory Effect of Streptozotocin on Tumor Development in Transgenic Mice Bearing an Elastase I-SV40 T-Antigen Fusion Gene
- 1 July 1991
- journal article
- research article
- Published by Wolters Kluwer Health in Pancreas
- Vol. 6 (4) , 475-478
- https://doi.org/10.1097/00006676-199107000-00016
Abstract
Transgenic mice, bearing a fusion gene of rat elastase I promoter and SV40 T-antigen, developed acinar cell tumors of the pancreas, as predicted by the model. In addition, they developed insulinomas and somatostatin (ω)-cell hyperplasia of the pancreatic islets, The insulinomas and the ω-cell hyperplasia appeared to be functional, as evidenced by changes in plasma glucose, insulin, and somatostatin. Streptozotocin, which has been shown to inhibit pancreatic carcinogenesis in the hamster model, significantly reduced the numbers of insulinomas and ω-cell hyperplasias. Streptozotocin did not cause a statistically significant reduction in exocrine tumors.Keywords
This publication has 0 references indexed in Scilit: