METABOLISM OF METHOTREXATE IN MAN AFTER HIGH AND CONVENTIONAL DOSES
- 1 January 1980
- journal article
- research article
- Vol. 28 (3) , 551-561
Abstract
Methotrexate, an antineoplastic drug, was extensively metabolized to 7-hydroxymethotrexate in patients receiving conventional doses (< 10 mg/kg) and high doses (> 10 mg/kg). At 12 h after administration, plasma levels of the metabolite in several patients treated with low doses exceeded those of methotrexate. No 7-hydroxymethotrexate was found in CSF after CNS administration of methotrexate, but small amounts of the metabolite were found in the CSF after i.v. high dose infusion. Methotrexate is significantly metabolized in man at all doses used clinically.This publication has 9 references indexed in Scilit:
- The ommaya reservoir.Newly recognized complications and recommendations for insertion and useCancer, 1978
- HIGH-PRESSURE LIQUID-CHROMATOGRAPHIC DETERMINATION OF METHOTREXATE AND ITS MAJOR METABOLITE, 7-HYDROXYMETHOTREXATE, IN HUMAN-PLASMA1978
- Clinical Pharmacokinetics of Methotrexate1Clinical Pharmacokinetics, 1978
- PRIMATE MODEL FOR STUDY OF METHOTREXATE PHARMACOKINETICS IN CENTRAL NERVOUS-SYSTEM1977
- Methotrexate in blood, urine, and cerebrospinal fluid of children receiving high doses by infusion.Clinical Chemistry, 1976
- 7-Hydroxymethotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high dose methotrexate.Journal of Clinical Investigation, 1976
- METABOLIC FATE OF TRITIATED METHOTREXATE .2. ABSORPTION AND EXCRETION IN MAN1965
- Methotrexate Displacement in Man*Journal of Clinical Investigation, 1964
- THE FLUOROMETRIC MEASUREMENT OF THE ABSORPTION, DISTRIBUTION AND EXCRETION OF SINGLE DOSES OF 4-AMINO-10-METHYL PTEROYLGLUTAMIC ACID (AMETHOPTERIN) IN MAN1958