Absence of Gene Interaction in Mouse Hybrids, Revealed by Studies of Immunological Tolerance and Homotransplantation.

Publisher Website
Google Scholar
Abstract
Summary and conclusions 1. C3H mice made tolerant by injection of A spleen cells at birth are tolerant of skin homografts from A strain and (A x C3H) F1 donors. 2. C3H mice made tolerant by injection of (A x C3H) F1 spleen cells at birth are tolerant of skin homotransplants from both A strain and (A x C3H) F1 donors. These observations are interpreted as evidence indicating that new histocompatibility antigens do not derive from genie interaction during hybridization in the 2 inbred strains of mice in these studies.