Human Coronavirus 229E: Receptor Binding Domain and Neutralization by Soluble Receptor at 37°C
Open Access
- 1 April 2003
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 77 (7) , 4435-4438
- https://doi.org/10.1128/jvi.77.7.4435-4438.2003
Abstract
Truncated human coronavirus HCoV-229E spike glycoproteins containing amino acids 407 to 547 bound to purified, soluble virus receptor, human aminopeptidase N (hAPN). Soluble hAPN neutralized the infectivity of HCoV-229E virions at 37°C, but not 4°C. Binding of hAPN may therefore trigger conformational changes in the viral spike protein at 37°C that facilitate virus entry.Keywords
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