Direct Spinal Effect of a Benzodiazepine (Midazolam) on Spasticity in Man
- 1 January 1989
- journal article
- research article
- Published by S. Karger AG in Stereotactic and Functional Neurosurgery
- Vol. 53 (2) , 85-94
- https://doi.org/10.1159/000099523
Abstract
The water-soluble benzodiazepine, midazolam, was administered epidurally over the lumbar enlargement 18 times to 9 patients with spasticity due to severe spinal cord injury. Doses of 1.25-3.75 mg produced a rapid decrease of spasticity which lasted 1 h. After the maximal reduction of spasticity, the patients became drowsy. While the results suggest a direct action of midazolam on the spinal cord to reduce spasticity, the effect does not contribute to its usefulness as a therapeutic tool.Keywords
This publication has 3 references indexed in Scilit:
- DYNAMIC MOTOR CAPACITY IN SPASTIC PARESIS AND ITS RELATION TO PRIME MOVER DYSFUNCTION, SPASTIC REFLEXES AND ANTAGONIST CO-ACTIVATION1980
- Effect of a water soluble benzodiazepine on the responses of spinal neurones to acetylcholine and excitatory amino acid analoguesNeuropharmacology, 1978
- Reflex effects of vibration in patients with spinal cord lesionsNeurology, 1977