CONJUNCTIVAL TRANSPORT OF TECHNETIUM-99m PERTECHNETATE

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Abstract
Using a .gamma. camera coupled to a computer and a tape unit the transport of pertechnetate (Tc99m) across the conjunctiva was determined by the region of interest technique in human subjects. In 11 patients with their lacrimal sacs removed the fractional turnover rate was 0.021 min-1. In 21 patients with inflamed conjunctiva due to chronic dacryocystitis the fractional turnover rate was 0.027 min-1. The value in 11 normal individuals was 0.015 min-1. Neglecting the relatively small transcorneal route of disapperance, the values found for technetium disappearance may be representative for the transconjunctival transport of the radioisotope. This assumption was confirmed by correlating the radioactivity in the blood with the fractional turnover rate.

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