Systematic Search for a Systemic Hydatid Scolicide

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Abstract
Sixty-four chemicals representing groups of alkylating agents, chelating agents, redox inhibitors, antimetabolites and miscellaneous chemicals were tested for their in vitro scolicidal action upon the hydatid scolices of Echinococcus granulosus. Scolices death was determined by their motility and staining properties and confirmed by their ability to undergo cystic development when inoculated i. p. into young albino mice. Thirteen chemicals displayed effective scolicidal activity after 10 min of exposing the scolices to the chemical. Of these 9 were effective in 5 min and 7 in 1 min. All the chemicals were of organic nature amenable to structural modifications which might lead to drugs useful in systemic treatment and prophylaxis of hydatid disease. The lethal dose (LD50) and scolicidal value of each chemical were determined. The significance of these findings is discussed.

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