Late motor involvement in cases presenting as “chronic sensory demyelinating polyneuropathy”

Publisher Website
Google Scholar
Abstract
Chronic inflammatory demyelinating polyneuropathy (CIDP) is usually characterized by prominent motor deficits. A pure sensory presentation, labeled chronic sensory demyelinating neuropathy (CSDN), has been reported, but it is unclear if this neuropathy is a distinct clinical and immunologic entity or merely the sensory presentation of the more usual sensorimotor CIDP. We describe 5 patients with what initially appeared to be CSDN; 3 subsequently developed substantial weakness coincident with the electrophysiologic appearance of multifocal motor conduction block. These cases indicate that, in some cases, CSDN may be a transitional clinical stage of CIDP in which the more usual sensorimotor deficits develop later. Immune‐based therapy, including intravenous immunoglobulin, was found to be effective in both the pure sensory and sensorimotor types. © 1995 John Wiley & Sons, Inc.