Importance of Dynamic Properties of Idiotopes in Interactions with Anti-Id Antibodies
- 1 January 1992
- journal article
- review article
- Published by Taylor & Francis in Immunological Investigations
- Vol. 21 (1) , 71-83
- https://doi.org/10.3109/08820139209069364
Abstract
The concept of fluctuating confomational substates in equilibrium characterizing variable-regions of immunoglobulin idiotypes is discussed in terms of the dynamic properties of idiotopes and their stabilization upon interactions with anti-idiotope antibodies. Uniquely, polyclonal anti-Id antibodies are viewed in cooperative immobilizing interactions with the idiotopes thereby facilitating formation of stable complexes.Keywords
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