Shear stress‐induced shedding of soluble intercellular adhesion molecule‐1 from saphenous vein endothelium
Open Access
- 9 April 2004
- journal article
- Published by Wiley in FEBS Letters
- Vol. 564 (1-2) , 161-165
- https://doi.org/10.1016/s0014-5793(04)00337-0
Abstract
Within 6 h, shear stress upregulated intercellular adhesion molecule‐1 (ICAM‐1) (two‐ to four‐fold, PP<0.001) and MMP‐9 had been induced. Inclusion of a hydroxamate metalloproteinase inhibitor partially reversed the effects on ICAM‐1 and sICAM‐1 at 8 h, whereas TIMP‐1, ‐2 or ‐3 had no effect. MMP‐9, but not MMP‐2, co‐immunoprecipitated with ICAM‐1. sICAM‐1 was processed distal to Arg441, indicating that MMP‐9, docking to ICAM‐1, contributes to sICAM‐1 shedding and attenuation of the shear stress‐induced upregulation of ICAM‐1.Keywords
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