Neutralization of feline immunodeficiency virus by polyclonal feline antibody: simultaneous involvement of hypervariable regions 4 and 5 of the surface glycoprotein
- 1 August 1995
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 69 (8) , 5124-5127
- https://doi.org/10.1128/jvi.69.8.5124-5127.1995
Abstract
Sites involved in antibody-mediated neutralization of feline immunodeficiency virus were mapped by reciprocal exchange of envelope fragments or amino acids between molecular clones of feline immunodeficiency virus with different susceptibilities to neutralization by a polyclonal cat serum. Combinations of mutations within HV-4 or within HV-4 and HV-5 changed the susceptibility of the viruses to neutralizing antibody.Keywords
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