Quantitative importance of non-skeletal-muscle sources of Nτ-methylhistidine in urine
- 15 July 1980
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 190 (1) , 225-228
- https://doi.org/10.1042/bj1900225
Abstract
Direct measurement of N tau-methylhistidine turnover in skeletal muscle, skin and gastrointestinal muscle indicates that these three tissues contribute only 24.9, 6.8 and 9.8% of the total urinary excretion. Measurement of the decay rate of radioactively labelled N tau-methylhistidine in urine indicates that skeletal muscle accounts for 74.5% of the urinary excretion and this is probably an overestimate. These results suggest that the common assumption, that N tau-methylhistidine in urine originates almost entirely from skeletal muscle, may be wrong.This publication has 3 references indexed in Scilit:
- The kinetics of myofibrillar protein breakdown in perfused rat skeletal muscleBiochimica et Biophysica Acta (BBA) - General Subjects, 1979
- Fractional flux rates ofNτ-methylhistidine in skin and gastrointestine: the contribution of these tissues to urinary excretion ofNτ-methylhistidine in the ratBritish Journal of Nutrition, 1977
- Fractional catabolic rates of myosin and actin estimated by urinary excretion ofNT-methylhistidine: the effect of dietary protein level on catabolic rates under conditions of restricted food intakeBritish Journal of Nutrition, 1977