MANDELIC ACID IN THE TREATMENT OF INFECTIONS OF THE URINARY TRACT
- 28 November 1936
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 107 (22) , 1799-1800
- https://doi.org/10.1001/jama.1936.02770480031008
Abstract
In recent years the treatment of infections of the urinary tract has taken on a more scientific aspect. The older empirical methods which were efficacious in alleviating symptoms have been supplanted by newer forms of treatment which have a logical and predetermined basis and the value of which has been proved. Since Shohl and Janney1demonstrated that the growth of Escherichia coli was inhibited in urine at apHof 4.6 to 5.0, the question of combating infection of the urine has come steadily to the foreground. Clark2in 1931, searching for a means of acidifying the urine, used the ketogenic diet. Early observations soon revealed that a secondary factor was needed besides high acidity if bacillary infections of the urinary tract were to be eradicated. Fuller3proved this secondary factor to be beta-hydroxybutyric acid. Helmholz and Osterberg 4 have definitely shown that a certain concentration of this acid, which is an end product of the ketogenic diet, is needed along with a certain pH of urine if negative cultures of urine are to be obtained.Keywords
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