Effect of TGFβ on liver genes expression Antagonistic effect of TGFβ on IL‐6‐stimulated genes in Hep 3B cells

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Abstract
The effect of transforming growth factor beta (TGFβ) on the expression of a group of liver genes has been investigated in the hepatoma cell line Hep 3B. TGFβ induces a decrease of the basal level of apolipoprotein A‐II (ApoA‐II), retinol binding protein (RBP) α‐fetoprotein (αFp). Furthermore, TGFβ efficiently antagonizes the IL‐6‐induction of hemopexin (Hpx) and haptoglobin (Hp) and α1‐acid glycoprotein (AGP). These effects of TGFβ are apparently mediated by post‐transcriptional mechanism(s). These findings, together with previously reported data on the inhibitory effect of TGFβ on acute phase genes (e.g. ApoA‐I and albumin), suggest a role for TGFβ in the regulation of expression of liver genes.