Sweating Response to Local Heat Application

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Abstract
A local sweating response can be produced by local conduction heat to a skin area of 5 x 5 mm. Variation in the time of appln. of the heat stimulus markedly influences the surface threshold of local sweating. Environmental temps. between 70[degree] and 90[degree]F decrease the threshold. Increased humidity decreases the threshold. Parasympathomimetic agents can produce local sweating and can facilitate the heat-produced local sweating response. Further, increased environmental temp. increases the response to local injn. of acetylcholine. The temp. threshold for local sweating is raised by systemic admn. of atropine and by local injn. of procaine and hexamethonium. The time and temp. factors of the local sweating response can be explained by the assumption of a fixed temp. threshold at fixed tissue depth. The peripheral sweating mechanism is subject to facilitation or inhibition by the neurohumoral control; and the neural mechanism of sweating is markedly influenced by skin temp.

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