Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
Top Cited Papers
- 15 July 2005
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 309 (5733) , 476-481
- https://doi.org/10.1126/science.1113694
Abstract
Neurofibrillary tangles (NFTs) are the most common intraneuronal inclusion in the brains of patients with neurodegenerative diseases and have been implicated in mediating neuronal death and cognitive deficits. Here, we found that mice expressing a repressible human tau variant developed progressive age-related NFTs, neuronal loss, and behavioral impairments. After the suppression of transgenic tau, memory function recovered, and neuron numbers stabilized, but to our surprise, NFTs continued to accumulate. Thus, NFTs are not sufficient to cause cognitive decline or neuronal death in this model of tauopathy.Keywords
This publication has 26 references indexed in Scilit:
- Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal deathNature, 2004
- Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the ProteasomeNeuron, 2004
- Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoformsJournal of Neurochemistry, 2003
- Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 FibrilsScience, 2001
- Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APPScience, 2001
- Tau Filament Formation in Transgenic Mice Expressing P301L TauJournal of Biological Chemistry, 2001
- Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's diseaseAnnals of Neurology, 1997
- Control of Memory Formation Through Regulated Expression of a CaMKII TransgeneScience, 1996
- Neuropathological staging of Alzheimer lesions and intellectual status in Alzheimer's and Parkinson's disease patientsNeuroscience Letters, 1993
- A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal TauScience, 1991