Processing of mammalian tRNA transcriptsin vitro: different pre-tRNAs are processed along alternative pathways that contain a common rale-limiting step
Open Access
- 1 January 1986
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 14 (12) , 4849-4864
- https://doi.org/10.1093/nar/14.12.4849
Abstract
We have analyzed the pathways and kinetics of processing of mouse tRNA gene transcripts in vitro. Different transcripts are processed along two alternative pathways. The 3′ trailer sequence of the tRNAHis primary transcript is excised before the 5′ leader sequence. In contrast, for the tRNAGly primary transcript, the 5′ leader sequence is excised before the 3′ trailer sequence, as has been found for other monomeric eukaryotic tRNA gene transcripts.Keywords
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