S1-receptor participation in serotonin-induced pulmonary edema in the dog.
- 1 January 1987
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 45 (1) , 121-124
- https://doi.org/10.1254/jjp.45.121
Abstract
A canine lung-perfusion preparation was used to evaluate the role of serotonin receptor subtype in the development of serotonin-induced pulmonary edema. Ketanserin, an S2-receptor antagonist, blocked an increase in pulmonary arterial pressure caused by serotonin, but not the development of pulmonary edema. Methysergide, an S1- and S2-receptor antagonist, prevented the increase in pulmonary arterial pressure and edema formation caused by serotonin. These results suggest that the S1-receptor may participate in the development of pulmonary edema.This publication has 0 references indexed in Scilit: