The efficacy of chloroquine for the treatment of acute, uncomplicated,Plasmodium falciparummalaria in Laos
- 1 September 2002
- journal article
- clinical trial
- Published by Taylor & Francis in Pathogens and Global Health
- Vol. 96 (6) , 553-557
- https://doi.org/10.1179/000349802125001654
Abstract
To assess the local efficacy of chloroquine for the treatment of acute, uncomplicated, Plasmodium falciparum malaria, children and adults from Sekong province (an area of Laos with a low intensity of transmission) were tested in a 28-day, in-vivo study. Complete data were collected from 88 of the 102 subjects enrolled between October 1999 and September 2000. After genotypic analysis to distinguish recrudescing infections from re-infections, 35 (39.7%, with a 95% confidence interval of 29.5%-50.7%) of these 88 patients were considered treatment failures. These results seriously question the use of chloroquine as the first-line treatment for P. falciparum malaria in the study areaKeywords
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