INDIRECT EVIDENCES OF PROLACTIN INVOLVEMENT IN PRECOCIOUS PUBERTY INDUCED BY HYPOTHALAMIC LESIONS IN FEMALE RATS
- 1 May 1977
- journal article
- research article
- Published by Bioscientifica in Acta Endocrinologica
- Vol. 85 (1) , 11-17
- https://doi.org/10.1530/acta.0.0850011
Abstract
The effects of 2-bromo-.alpha.-ergocryptine (CB-154) administration in maturing female rats with precocious puberty induced by hypothalamic lesions, and the milk secretion rate in these animals after their 1st parturition were studied. Treatment with CB-154 inhibited precocious vaginal opening induced by hypothalamic lesions. After treatment with the derivative was terminated, the ovulatory response was not different from that of intact control rats. After their 1st parturition lesioned rats accumulate milk at a faster rate, following an initial depletion period, than their non-operated controls. An alteration in prolactin release may be involved in determining the precocious puberty induced by lesions of the anterior hypothalamic area.This publication has 1 reference indexed in Scilit:
- THE EFFECT OF HYPOTHALAMIC DEAFFERENTATION UPON PUBERTY IN THE FEMALE RATActa Endocrinologica, 1967