Cloning and characterisation of the rabbit 5‐HT1Dα and 5‐HT1Dβ receptors
- 11 December 1995
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 377 (1) , 73-76
- https://doi.org/10.1016/0014-5793(95)01308-3
Abstract
The genes encoding the rabbit 5HT1Dα and 5HT1Dβ receptors have been cloned. The deduced amino acid sequence of these receptors shows 91–92% amino acid sequence identity with their human homologues, and similar high sequence identity with homologues from other species. The receptors were transiently expressed in COS-7 cells and exhibit a pharmacological profile closely resembling their human homologues, including a higher affinity of ketanserin for the 5-HT1Dα subtype. However, sumatriptan had a lower affinity for both the rabbit receptors compared to their human counterparts. This may be accounted for by differences between the primary amino acid sequences of these species homologues.Keywords
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