EM–Autoradiographic Studies on the Inflammatory Cells in the Experimental Japanese Encephalitis

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Abstract
Four adult mice were injected with 3H–thymidine repeatedly for 90 hours. One of them was sacrificed 12 hours after the last injection. At this period almost all of circulating leukocytes were labeled, whereas the number of labeled cells in the brain was negligible. Then Japanese encephalitis virus was inoculated and the infected brains were investigated by electron microscopic autoradiography. Following results were obtained. (1) Almost all of the inflammatory cells appearing in the infected brains are derived from circulating mononuclear cells especially mono–cytes. (2) In the Japanese encephalitis monocytes are tend to transform to cells which have a large amount of cytoplasm with dense matrix and a small number of intracellular organellae located at one pole of their cytoplasm. They are plump in shape and showed pseudopodia or ruffles. (3) Many mononuclear leukocytes were found being in the process of extravasation and their morphology was described.

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