Sertraline in paired blood plasma and breast-milk samples from nursing mothers

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Abstract
Paired blood and breast‐milk samples were collected from 10 nursing mothers receiving sertraline. Samples were collected at steady state when the patients had been taking stable doses of 50–150 mg/day over several weeks. Sertraline concentrations in both fluids were determined using a specific, validated HPLC method. Plasma and milk concentrations showed a wide inter‐individual variability for the same dose. Mean plasma concentrations were linearly related to dose, but this was not the case for breast‐milk concentrations. An overall milk to plasma ratio of 1·76±1·72 was recorded. The average dose to the infants ranged from 1·1 to 31·1 μg/kg, which is less than 2 per cent of the maternal dose per day. Further studies are necessary to determine if these doses are detrimental to the development of the infant. Copyright © 2000 John Wiley & Sons, Ltd.

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