EFFECTS OF BREATHING GASES CONTAINING OXYGEN AND CARBON DIOXIDE AT 1 AND 3 ATMOSPHERES PRESSURE ON BLOOD FLOW AND OXYGENATION OF TUMORS
- 1 January 1967
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 45 (1) , 49-56
- https://doi.org/10.1139/y67-005
Abstract
Mice with established, immunologically compatible tumors were allowed to breathe air, O2, or 5% CO2 and 95% O2 at 1 and 3 atmospheres pressure. Tumor blood flow was determined by using the thermal circulation index, and oxygenation was measured polarographically. Pure oxygen at 1 atmosphere had no significant effect on blood flow within the tumor and in normal skin, but inhalation at 3 atmospheres decreased flow within both tissues. The addition of 5% CO2 to the oxygen increased flow at both pressures. Oxygenation was often improved in anoxic areas within the tumor on breathing 100% O2 at 1 atmosphere and in almost all animals at 3 atmospheres; the addition of 5% CO2 at either pressure usually further improved the oxygenation, but sometimes had the opposite effect at 3 atmospheres. The application of these results to the use of hyperbaric O2 in radiotherapy is discussed.This publication has 1 reference indexed in Scilit:
- Effect of High Pressure Oxygen on Radiosensitivity of Ehrlich's Tumour in Mice After “Immunological Approximation”British Journal of Cancer, 1961