Nonlinear desipramine pharmacokinetics: a case study.
- 1 February 1985
- journal article
- case report
- Vol. 5 (1) , 43-5
Abstract
A case of nonlinear desipramine pharmacokinetics is described. During routine clinical monitoring serum desipramine concentrations appeared to change disproportionately with dose. Following a series of controlled dosage decreases, from 400 to 50 mg/day, the patient's steady state serum concentrations fit a nonlinear pharmacokinetic model. This curvilinear serum concentration-dose relationship suggests saturation of hepatic metabolism and signals the need for caution when predicting or titrating doses against serum drug concentrations. The implications of this new finding are discussed.This publication has 0 references indexed in Scilit: