Inhibitory Effects of Retinoic Acid or Retinyl Acetate on the Growth of Untransformed, Transformed, and Tumor Cells In Vitro 2
- 1 December 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 59 (6) , 1717-1722
- https://doi.org/10.1093/jnci/59.6.1717
Abstract
The ability of vitamin A derivatives (“retinoids”) to inhibit the growth of 31 untransformed, transformed, or tumor celliines was investigated in vitro. Two retinoids, retinyl acetate and, to a greater extent, retinoic acid (10−5 M), inhibited the growth of certain transformed and tumor cells. According to their sensitivity to these retinoids, cells were divided into the following categories: a) cells not affected (<10% inhibition) or only slightly inhibited (75%), such as murine melanomas B16 and S91, rat mammary adenocarcinomas 13762NF and DMBA#8, murine lymphosarcoma RAW117 and myeloma P3, human lymphoid cell line RPMI 1788, and Burkitt's lymphoma (DAUDI). The findings showed that the growth of a considerable number of transformed and tumor cells could be inhibited in vitro by retinoids and suggested that the previously observed antitumor activity of retinoids in vivo is at least partly due to direct inhibition of cell proliferation.Keywords
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