Autoxidation of phosphatidylcholine liposomes

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Abstract
Autoxidation of pure soybean phosphatidylcholine [PC] liposomes at 40.degree. C proceeded without an observed induction period, but otherwise, the rates of disappearance of the linoleic acid (70% of total) and linolenic acid (6% of total) followed typical autocatalytic kinetics. Incorporation of 0.05 mol% of tocopherol into the liposomes produced an induction period of about 7 h under the condition used for the incubation. The products formed from the autoxidation of pure soybean PC liposomes were mostly 9- and 13-hydroperoxyoctadecadienoates (isolated as hydroxy esters). The yield of hydroperoxides with cis, trans configuration was about the same as those with trans,trans configuration throughout the incubation period. After extensive autoxidation, a large quantity of trihydroxyoctadecenoate was also produced. When a large quantity of dipalmitoyl phosphatidylcholine was incorporated into soybean PC liposomes, the rate of autoxidation decreased and conformed to apparent first-order kinetics. In this system, the yield of trans,trans hydroperoxides was much greater than that of cis,trans isomers at all stages of autoxidation. Late in the autoxidation of the mixed liposomes, both trihydroxyoctadecenoate and hydroxyepoxyoctadecenoate were produced in substantial quantities.

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