Novel 1,4-asymmetric induction in nucleophilic 1,2-additions to chiral γ-amino enals
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 18,p. 1309-1311
- https://doi.org/10.1039/c39910001309
Abstract
γ-Dibenzylamino enals 3a with the E-configuration derived from amino acids 1 react diastereoselectively with cuprates in an unexpected 1,2-manner, while the analogues 3b with the Z-configuration undergo diastereoselective additions with organolithium reagents.Keywords
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