Prognostic Significance of PCNA Expression in Laryngeal Cancer

Open Access

1 December 1998

journal article
research article
Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery

Vol. 124 (12) , 1321-1324
https://doi.org/10.1001/archotol.124.12.1321

Abstract

PREDICTING THE outcome of laryngeal cancer is of paramount importance for the physician to decide on the treatment modality. Despite the many investigations on cytologic and morphologic properties, currently there are no absolute criteria that can predict the outcome of laryngeal cancer and guide the physician to select the appropriate therapy and to decide on the extent of surgery and the convenience of neck dissection in patients with N0 tumors. One of the most important criteria that shows the aggressive biological behavior is the cellular proliferation rate of a tumor. Consequently, several proliferation markers have been studied for their relation with the recurrence and metastatic rate of the tumor and mortality.

Keywords

This publication has 15 references indexed in Scilit:

Tumor-associated tissue eosinophilia and long-term prognosis for carcinoma of the larynx
The American Journal of Surgery, 1994
Prediction of early relapse and shortened survival in patients with breast cancer by proliferating cell nuclear antigen score
Cancer, 1993
Proliferating cell nuclear antigen (PCNA) expression and nuclear DNA content in predicting recurrence after radiotherapy of early glottic cancer
Oral Oncology, 1993
Prognostic significance of the PC10 index as a prospective assay for cervical cancer treated with radiation therapy alone
Cancer, 1992
Argyrophilic nucleolar organizer region counts and proliferating cell nuclear antigen scores are two reliable indicators of survival in pharyngeal carcinoma
Zeitschrift für Krebsforschung und Klinische Onkologie, 1992
Prognostic value of proliferating cell nuclear antigen in gastric carcinoma.
Journal of Clinical Pathology, 1991
Cell cycle-dependent variations in the distribution of the nuclear protein cyclin proliferating cell nuclear antigen in cultured cells: subdivision of S phase.
Proceedings of the National Academy of Sciences, 1985
PROGNOSTIC VALUE OF VASCULAR INVASION IN SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Plastic and Reconstructive Surgery, 1978
A Correlation of Clinical Staging, Pathological Findings and Five Year end Results in Surgically Treated Cancer of the Larynx
Annals of Otology, Rhinology & Laryngology, 1970
The incidence of cervical lymph node metastases from epidermoid carcinoma of the larynx and their relationship to certain characteristics of the primary tumor.A study based on the clinical and pathological findings for 96 patients treated by primary en bloc laryngectomy and radical neck dissection
Cancer, 1961