Polyadenylic {middle dot} Polyuridylic Acid in the Cotreatment of Cancer
- 1 May 1985
- journal article
- clinical trial
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 179 (1) , 1-8
- https://doi.org/10.3181/00379727-179-42055
Abstract
The biological properties of polyadenylic . polyuridylic acid (Poly(A) . Poly(U] are discussed and the application to the treatment of cancer in various animal models is described. Pharmacokinetic properties are presented and the results of clinical application to humans with specific reference to adjuvant treatment of breast cancer are examined in some detail. Given these results and the total lack of toxicity or of secondary effects of Poly(A) . Poly(U) it appears that further development and application of this polynucleotide complex are certainly justified in terms of clinical use in cancer and perhaps in viral pathologies.Keywords
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