Health Status of Adult Long-term Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study
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Open Access
- 24 September 2003
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 290 (12) , 1583-1592
- https://doi.org/10.1001/jama.290.12.1583
Abstract
The development of curative therapy for most pediatric malignancies provides the opportunity to investigate the impact of cancer treatment on health status of large numbers of long-term survivors. Numerous studies have established that cancer and its treatment predispose to late morbidity and increase the risk of early mortality in long-term childhood cancer survivors.1-8 In general, children with aggressive tumor histologies have required more intensive treatment, which predispose them to heightened risks of physical morbidity. Treatment-related late sequelae with significant potential impact on physical functioning include neurocognitive dysfunction, cardiopulmonary toxicity, endocrinopathy, and second malignancy. The frequency and severity of many of the common sequelae have been correlated with sex, age at diagnosis, and cumulative dose-exposures of specific treatment modalities.9-12Keywords
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