Congenital Dyserythropoietic Anaemia Type III: an Electron Microscopic Study

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Abstract
The morphological features of [human] erythroblasts in congenital dyserthropoietic anemia (CDA) type III were studied by EM. Typical findings included clefts and blebs within the nuclear region, autolytic areas within cytoplasm, Fe-filled mitochondria and myelin figures. The findings resembled those reported in other dyserythropoietic anemias particularly in CDA type I; the main morphologic features which distinguished the 2 types were lack of spongy appearance of the chromatin, lack of cytoplasmic organelles within the nuclear region and intact nuclear envelope in CDA type III.