Optically Active Arylpropionic Acids from the Stereoselective Alkylation of Chiral Imide Enolates1
- 1 January 1992
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1992 (01) , 48-50
- https://doi.org/10.1055/s-1992-21261
Abstract
The chiral imides 4 - 6 (3-arylacetyl-4-isopropyl/benzyl-2-oxazolidinones) were alkylated via their imide enolates with methyl iodide, then subsequent removal of the chiral auxiliary provided readily with high stereoselectivity the (S)-2 -arylpropionic acids 1 - 3 in good overall yield.Keywords
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