A study of the excretion of organic antimonials using a polarographic procedure

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Abstract
Sb is detd. in biological materials by a rapid polarographic method. Urine is made normal to HC1, 1% gelatin added and SbIII detd. directly. Sbv is detd. similarly after reduction with Na2SO3. Total Sb in blood is detd. directly after refluxing with 10% HC1 (90-100% recovery), and SbIII after precipitation of protein with snlphosalicylic acid from a 1:20 dilution of blood (80% recovery). The urinary excretion of the SbIII compounds[long dash]tartar emetic (I), anthiomaline (II), stibophen (III) and the Sbv compounds[long dash]stibacetin (IV), neostam (V), neo-stibosan (VI), ureastibamine (VII), Na antimonyv gluconate (VIII), was followed in mice. III, V, and VIII were studied in a few human subjects. With all the Sbv compounds 30-40% of the Sb was eliminated in the first 1-2 hrs. after inj.; III was excreted much more slowly than an equivalent dose of VIII. No measurable blood Sb could be detected 3-4 hrs. after inj. of any compound. Sb excreted during the first 24 hrs. was unchanged in valency, but a small amt. of SbIII was detected in later urine samples and in the livers of animals injected with VIII. Incubation of VIII with blood, liver brei or slices, and chick tissue culture produced a small but definite reduction to SbIII.

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