PREDICTION OF THE FREQUENCIES OF RESTRICTION ENDONUCLEASE RECOGNITION SEQUENCES USING DINUCLEOTIDE AND MONONUCLEOTIDE FREQUENCIES

  • 1 January 1988
    • journal article
    • research article
    • Vol. 6  (1) , 34-+
Abstract
The calculation of probabilities of nucleotide sequences from the frequencies of dinucleotides is described. The dinucleotide and mononucleotide frequenceis used can be obtained from nearest neighbor analysis or from databank sequences. If dinucleotide and mononucleotide frequencies from nearest neighbor analysis are used, probabilities for oligonucleotides can be calculated for genomes in which there is little or no sequence data. Within a given genome, a broad range of probabilities for hexanucleotide palindromes with the same base composition is predicted and shown (14).