Effect of Rat Stalk Median Eminence Extracts on Rat GH Secretion In vivo

1 January 1976

journal article
research article
Published by S. Karger AG in Hormone Research

Vol. 7 (4-5) , 274-279
https://doi.org/10.1159/000178738

Abstract

Estradiol (0.2 µg), injected subcutaneously for 10 days to adult male rats, increased plasma growth hormone (GH) levels as compared with oil-treated controls. In estradiol-pretreated (10 days), urethane-anesthetized rats, the first as well as the second of two successive intracarotid injections, at 1-hour intervals, of one rat stalk median eminence equivalent evoked a significant rise in plasma radioimmunoassayable GH. Under the same conditions, cerebral cortex extracts (1 equivalent) induced a slight elevation whereas vasopressin (30 mU) or serotonin (200 ng) were ineffective. These results indicate that estrogenprimed, urethane-anesthetized rats can be used to demonstrate GH-releasing activity in rat SME extracts.

Keywords

This publication has 1 reference indexed in Scilit:

Growth Hormone-Releasing Activity of Hypothalamic Extracts at Different Ages
Endocrinology, 1965