Synthesis of [11C]‐sarin
- 1 June 1990
- journal article
- research article
- Published by Wiley in Journal of Labelled Compounds and Radiopharmaceuticals
- Vol. 28 (6) , 645-651
- https://doi.org/10.1002/jlcr.2580280604
Abstract
[11C]‐acetone, prepared from 11CO2 and methyllithium, was reduced to [11C]‐isopropanol. The latter reacted with methylphosphonic acid difluoride in the presence of diisopropylamine, to yield [11C]‐sarin.3.4 GBq (100 mCi) of [11C]‐sarin may be obtained from about 55.5 GBq (1.5 Ci) of 11CO2 in 40 minutes. The product purified by HPLC, is obtained with a specific radioactivity ranging from 22.2 to 33.3 GBq (600 to 900 mCi/μmol.).Keywords
This publication has 4 references indexed in Scilit:
- Synthesis of specific labelled [methyl‐14C]sarinJournal of Labelled Compounds and Radiopharmaceuticals, 1988
- Synthesis of carbon-11-labelled acetoneThe International Journal of Applied Radiation and Isotopes, 1980
- Blood-brain barrier permeability of 11C-labeled alcohols and 15O-labeled waterAmerican Journal of Physiology-Legacy Content, 1976
- A new and rapid colorimetric determination of acetylcholinesterase activityBiochemical Pharmacology, 1961