Studies on synthesis of optically active twelve-membered diynes: a convergent construction of a twelve-membered diketodiyne compound with C2 symmetry
- 7 February 2000
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 5,p. 737-744
- https://doi.org/10.1039/a909089d
Abstract
A convergent procedure for the preparation of optically active twelve-membered diketodiyne derivatives with C2 symmetry possessing four hydroxy functionalities was developed starting from the commercially available diethyl L-tartrate. The key step for the construction of the twelve-membered diyne framework involved an intramolecular chromous chloride-mediated coupling reaction between the aldehyde functionality and the alkyne moiety having an iodine atom at its terminus.Keywords
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