Neonatal hypocalcaemia after intrauterine exposure to anticonvulsant drugs.
- 1 March 1977
- journal article
- research article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 52 (3) , 239-241
- https://doi.org/10.1136/adc.52.3.239
Abstract
Two cases are reported of prolonged hypocalcemia with tetany in infants born at term, whose mothers had been treated with phenytoin and phenobarbitone in high doses. Both infants presented with jitteriness and tetany in the 1st and 2nd wk of life, and in both the hypocalcemia was resistant to therapy over a longer period. An effect on the fetal vitamin D metabolism by phenytoin and phenobarbitone, resulting in defective bone mineralization and neonatal hypocalcemia is suggested.This publication has 8 references indexed in Scilit:
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