Immunosuppression induced by "toxohormone" from mouse tumor cells in culture.
- 1 January 1979
- journal article
- research article
- Published by Tohoku University Medical Press in The Tohoku Journal of Experimental Medicine
- Vol. 128 (3) , 233-239
- https://doi.org/10.1620/tjem.128.233
Abstract
Tumor culture toxohormone (TCT) obtained from cultures of MBQA mouse tumor cells, a line derived from a methylcholanthrene-induced fibrosarcoma (CBA/J origin), suppressed the mitogenic responsiveness of mouse spleen cells (PHA [phytohemagglutinin], LPS [lipopolysaccharide]) as well as the antibody formation to SRBC [sheep red blood cells] in vitro. The immunosuppressive activity of toxohormone was readily inactivated by heating at 100.degree. C or treatment with trypsin, but not by DNase and RNase treatment.This publication has 6 references indexed in Scilit:
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