Nonlinear dynamics, complex systems, and the pathobiology of critical illness

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Abstract
The review considers problems in critical illness and critical care in the context of complex systems science. Normal physiology is characterized by nonlinear dynamics, and it appears that the pathophysiology of critical illness alters those dynamics. Recent evidence confirms and extends the observation that the rich variability that characterizes normal physiology "decomplexifies" with critical illness. Experimental data in animals and now in humans suggests that physiologic support that mimics normal variability may reduce the severity and/or duration of the illness. Physiologic dynamics in health and in critical illness appear to reflect complex, interconnected systems biology. Alterations in illness and during recovery may provide important clues to the underlying structure of the system. With knowledge of the structure, therapy could be better focused toward supporting both function and dynamics, offering hope for improved outcomes.