ANTAGONISM OF THE EFFECT OF ISOPRENALINE ON HEART RATE BY PILOCARPINE

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Abstract
1 The interaction of pilocarpine and isoprenaline on heart rate was investigated in the spontaneously beating, right isolated atrium of the rat. 2 The log dose-effect curve of isoprenaline, measured in the presence of various concentrations of pilocarpine, was not modified when the concentration of the latter did not exceed 10−6 m even though significant slowing of the heart had occurred. At concentrations higher than 10−6 m a rapid but graded shift to the right of isoprenaline response curves occurred so that at pilocarpine 10−5 m the pD2 of isoprenaline was reduced from 11 to 3.3; cocaine slightly reduced this antagonism. 3 It is concluded that pilocarpine antagonizes isoprenaline by some mechanism which is not of the simple competitive type.