The logic of TGFβ signaling
Top Cited Papers
- 21 April 2006
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 580 (12) , 2811-2820
- https://doi.org/10.1016/j.febslet.2006.04.033
Abstract
The identification of the TGFbeta cytokine signaling pathway, including membrane receptor serine/threonine kinases and Smad transcription factors as their substrates, has allowed the delineation of a process for conversion of these signals into programs of gene activation and repression that underlie critical cell fate and developmental decisions. The deconstruction of one of these responses - the cell cycle arrest response - into its elemental molecular parts has shed light into the mechanisms used by tumors to evade surveillance and cause metastasis.Keywords
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