New anthracycline disaccharides. Synthesis ofL-daunosaminyl-α(1 →4)-2-deoxy-L-rhamnosyl and ofL-daunosaminyl-α(1 →4)-2-deoxy-L-fucosyl daunorubicin analogues

Publisher Website
Google Scholar
Abstract
The synthesis of the new disaccharide anthracyclines 20, 21, 24 and 25, where the daunosamine moiety is separated from the aglycone by either a rhamnose or a fucose residue, performed following a convergent procedure, gives insight into the configurational requirement of the first sugar residue and opens the way to a new class of antitumour anthracyclines.

This publication has 16 references indexed in Scilit: