Hemoglobin Parchman: Double Crossover Within a Single Human Gene
- 15 October 1982
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 218 (4569) , 291-293
- https://doi.org/10.1126/science.7123235
Abstract
Structural analysis of a new variant hemoglobin revealed tryptic peptides with the amino acid composition of normal delta-globin, except for two internal peptides, which had the compositions of normal beta-globin. The most likely explanation for these findings is that a double, nonhomologous crossover between the delta-and beta-globin genes had occurred.Keywords
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